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Poster abstracts

Pedersen CB, Ovesen T, Mirz F, Madsen S, Johannsen P, Ishizu K, Gjedde A. Evaluation of time discrimination in auditory perception. Neuroimage 1997; 5(4): 182.

Ishizu K, Johannsen P, Ovesen T, Mirz F, Gee A, Hansen SB, Pedersen CB, Gjedde A. PET maps of attention sites to non-semantic auditory stimuli. Neuroimage 1997; 5(4): 190.

Ishizu K, Mirz F, Ovesen T, Johannsen P, Gee A, Hansen SB, Pedersen CB, Gjedde A. Anatomical symmetry of brain activation: bilateral sites revealed by attention to auditory stimuli. Neuroimage 1998; 7(4): 83.

Ishizu K, Mirz F, Madsen S, Gee G, Gee A, Hansen SB, Pedersen CB, Gjedde A. Temporal pattern of brain activation: habituation to auditory stimuli.  Neuroimage 1998; 7(4): 366.

Mirz F, Pedersen CB, Ovesen T, Madsen S, Gjedde A. Brain mapping may reveal origins of tinnitus.  Neuroimage 1998; 7(4): 386.

Mirz F, Gjedde A, Stødkilde-Jørgensen H, Pedersen CB. Cortical activation in response to aversive auditory stimuli: a PET study. Neuroimage 1999; 9(6): 802.

Mirz F, Gjedde A, Stødkilde-Jørgensen H, Pedersen CB. Cortical activation associated with auditory temporal processing. Neuroimage 1999; 9(6): 795.

Seto E, and Mirz F, Stødkilde-Jørgensen H. Effects of sound pressure levels and frequency content of ambient MR scanner noise on visually stimulated fMRI. Neuroimage  1999; 9(6): 797.

Mortensen MV, Mirz F, Gjedde A. Linking psychophysics and neurophysiology: neuroimaging in Hearing. Danavox Proceedings. 24. August 2001.

Mirz F, Wetke R, Pedersen CB. A randomized, controlled prospective study of the efficacy of Tinnitus Retraining Therapy (TRT) - preliminary results. Fifth EFAS Congress. 16. - 20. september 2001, Bordeaux, Frankrig.

Mortensen MV, Mirz F, Pedersen CB, Gjedde A. Auditory cortical responses in cochlear implant users with different speech perception. Neuroimage 2002.



Peer reviewed articles

Mirz F, Jørgensen BG, Pedersen CB. Vestibularis-schwannom. Sygdommens incidens og konsekvenser heraf.  Ugeskr Læger 1998; 160: 6516-6519.

Mirz F, Jørgensen B, Fiirgaard B, Lundorf E, Pedersen CB. Investigations into the natural history of vestibular schwannoma.  Clin Otolaryngol 1999; 24: 13-18.

Pedersen CB and Mirz F Ny strategi i tinnitusbehandlingen. Ugeskr Laeger 1999; 160: 6221-6222.

Mirz F, Zachariae R, Andersen SE, Nielsen AG, Johannsen, LV, Bjerring P, Pedersen CB. The low-power laser in the treatment of tinnitus.  Clin Otolaryngol 1999; 24: 346-354.

Mirz F, Ovesen T, Ishizu K, Johannsen P, Madsen S, Gjedde A, Pedersen CB. Stimulus-dependent central processing of auditory stimuli: a PET study.Scand Audiol 1999; 28: 161-169.

Pedersen CB, Mirz F, Ovesen T, Ishizu K, Johannsen P, Madsen, S, Gjedde A. Cortical centers underlying auditory temporal processing in humans: a PET study. Audiology 2000;39:30-37.

Mirz F, Pedersen CB, Ishizu K, Johannsen P, Ovesen T, Stødkilde-Jørgensen H, Gjedde A. Positron emission tomography of cortical centers of tinnitus. Hear Res  1999; 134: 133-144.

Zachariae R, Mirz F, Johansen LV, Andersen SE, Bjerring P, Pedersen CB. Reliability and validity of a Danish adaption of the Tinnitus Handicap Inventory. Scand Audiol 2000; 29: 37-43.

Mirz F, Gjedde A, Stødkilde-Jørgensen H, Pedersen CB. Neuroanatomical correlates of induced tinnitus. Proceedings of the Sixth International Tinnitus Seminar, Cambridge, England, 323-327, 1999.

Mirz F, Pedersen CB, Fiirgaard B, Lundorf E. Incidence and growth pattern of vestibular schwannomas in a Danish County 1977-1998. Acta Otolaryngol (Stockh) 2000; Suppl  543: 30-33.

Mirz F, Gjedde A, Ishizu K, Pedersen CB. Cortical networks subserving the perception of tinnitus: a PET study. Acta Otolaryngol (Stockh) 2000; Suppl 543: 240-243.

Thomsen J, Mirz F, Wetke R, Astrup J, Bojsen-Møller M, Nielsen E. Intracranial sarcoma in a patient with NF2 treated with gamma-knife radiosurgery for vestibular schwannoma. Am J Otol 2000, 21: 364-370.

Mirz F, Zachariae R, Andersen SE, Nielsen AG, Johannsen, LV, Bjerring P, Pedersen CB. Behandling af tinnitus med lav-energi laser. Ugeskr. Laeger 2000, 162: 3607-10.

Mirz F, Gjedde A, Stoedkilde-Joergensen H, Pedersen CB. Functional brain imaging of tinnitus-like perception induced by aversive auditory stimuli.  Neuroreport 2000;11: 633-637.

Pedersen CB, Mirz F. Tinnitus. Ugeskr Prakt. Laegegerning 2002; 80: 463-470.

Mirz F, Mortensen MV, Gjedde A, Pedersen CB. Positron emission tomography of tinnitus suppression by cochlear implantation. Proceedings of the Seventh International Tinnitus Seminar, Fremantle, Australia, 136-140, 2002.

Mirz F, Mortensen MV, Madsen S, Gjedde A. Tinnitus suppression by cochlear implantation: a PET study. Proceedings of the International Conference on Auditory Cortex, Magdeburg, Germany, 79, 2003.

Mortensen MV, Mirz F, Madsen S, Gjdde A. Cortical activity during promontory stimulation in postlingually deaf adults evaluated by PET. Proceedings of the International Conference on Auditory Cortex, Magdeburg, Germany, 79-80, 2003.



Books and book chapters

Mirz F, Pedersen CB. Tinnitusbogen,  Munksgaard, Copenhagen 2002.

Mirz F. Øre-, næse-, halssygdomme (Chapter 11)  i Basisbog i sygdomslære. Munksgaard, Copenhagen 2005.



































Mirz F et al. Neuroanatomical correlates of induced tinnitus. Sixth International Tinnitus Seminar, Cambridge, UK.   (View proceeding)              

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Neuroanatomical correlates of induced tinnitus

Mirz F, Gjedde A, Stødkilde-Jørgensen H, Pedersen CB
Department of Otorhinolaryngology, PET-Centre, and MR-Research Centre
Aarhus University Hospitals

Recent models of tinnitus generation suggest that auditory phantom perception may arise from any aberrant signal within the auditory system. For all signals, the models claim that conscious perception takes place in the cerebral cortex. A few functional brain imaging studies addressed the cerebral mechanisms underlying such perception. To contrast conditions with and without tinnitus, most studies have concerned rare types of tinnitus (e.g., tinnitus changeable by oral-facial movement or eye gaze). These studies revealed variable activation of the auditory cortices and in one study of the hippocampus. In a recent PET study with intravenous lidocaine or acoustic masking to suppress tinnitus, the perception of tinnitus implicated activation of a right prefrontal-temporal network. Besides the evidence of activation of associative auditory sensory regions, these results also suggested that cortical centers subserving attention and memory may underlie the continuous annoyance associated with severe tinnitus.

The aim of the present study was to create a neuro-functional model of tinnitus. To imitate the auditory and emotional experiences associated with tinnitus in patients, we presented aversive sounds to normal volunteers. Based on our earlier brain imaging studies and theories of tinnitogenesis, we predicted that the perception of aversive auditory stimuli activates the auditory cortex, the emotional association centers of the limbic system, and the prefrontal lobes.

Seven right-handed, healthy volunteers participated in the study. Positron emission tomography (PET) was used to reveal the expected specific changes in cerebral activity. To induce a tinnitus-like experience, four sounds were selected from 20 different sounds generated on the basis of description of sounds perceived by tinnitus patients. To select the four sounds with the highest impact on the involved neuronal systems, ten subjects not involved in the PET study rated the aversion, dislike, nuisance, and disturbance caused by the sounds on a visual-analog-scale (100 mm). Five PET scans were obtained for each subject. Brain maps from scans with the induced tinnitus experience were contrasted to brain maps from a baseline condition in a subtraction procedure.

Analysis of the preliminary data revealed activation in the primary auditory cortex bilaterally (BA 41), the superior temporal gyri bilaterally (BA 22), other associative auditory areas in the left hemisphere (BA 21), prefrontal areas (right superior and middle frontal gyri, and inferior frontal gyri bilaterally, BA 6, 8, 9, 44, 45), and the limbic system (amygdalae and parahippocampal gyri bilaterally, BA 28, 34).

The results show that processing of aversive auditory stimuli by healthy volunteers elicits activity in neural systems similar to those demonstrated in different PET studies on patients with tinnitus. The consistent activation of primary and associative auditory cortices and limbic system structures confirm that these centers subserve auditory and emotional processing of aversive sounds. The results give indirect evidence for the hypothesis that activation in prefrontal areas may be the underlying neurophysiological substrate of the continuous attention directed towards tinnitus, as suggested in an earlier PET study on tinnitus patients.


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